Circadian rhythm abnormalities in bipolar disorder have led to a search for genetic abnormalities in circadian "clock genes" associated with BD. However, no significant clock gene findings have emerged from genome-wide association studies. At least three factors could account for this discrepancy: complex traits are polygenic, the organization of the clock is more complex than previously recognized, and/or genetic risk for BD may be shared across multiple illnesses. To investigate these issues, we considered the clock gene network at three levels: (...) essential "core" clock genes, upstream circadian clock modulators, and downstream clock controlled genes. Using relaxed thresholds for GWAS statistical significance, we determined the rates of clock vs. control genetic associations with BD, and four additional illnesses that share clinical features and/or genetic risk with BD. Then we compared the results to a set of lithium-responsive genes. Associations with BD-spectrum illnesses and lithium-responsiveness were both enriched among core clock genes but not among upstream clock modulators. Associations with BD-spectrum illnesses and lithium-responsiveness were also enriched among pervasively rhythmic clock-controlled genes but not among genes that were less pervasively rhythmic or non-rhythmic. Our analysis reveals previously unrecognized associations between clock genes and BD-spectrum illnesses, partly reconciling previously discordant results from past GWAS and candidate gene studies. (shrink)

Organizational leaders are eager to unlock the creative potential of followers. Yet, there is growing evidence that creativity can also have a dark side within organizations. Building on research linking creativity and unethical behavior, we develop the construct of creative unethicality—behavior that is both unethical and novel. We draw on social exchange theory to develop a model that identifies both why and when creative unethicality emerges within organizations. Specifically, we investigate the exchange dynamics through which creative support provided by empowering (...) leaders facilitates creative unethicality under conditions of high performance pressure. Across two multi-wave, multi-source field studies with employee-coworker and leader-subordinate dyads and an experimental study with a novel unethicality measure in a business simulation, we find convergent support for our theoretical model. These findings have important theoretical and practical implications for fostering creativity in organizations without simultaneously facilitating creative unethicality. (shrink)

Whilst the Neoliberal alludes to an array of very real material practices and axioms of contemporary capitalism, the concept of Neoliberalism itself has arguably become moribund. Worse, perhaps it has become an asphyxiating and enervating monolith, a ‘ptolemization’ from which our critical thinking cannot escape. The key strategy of the article is to explore the Neoliberalism concept as a ‘mode of telling’, and how the constitutive moments of that concept have been discursively constructed into a hegemonic discursive formation. Whilst the (...) resultant paradigm of Neoliberalism has ironically been constituted out of the identity-thinking and the synthetic historicizing of its very critics, the article searches for alternative avenues of reconstitutive deconstruction, so as to offer both critical optimism and a more effective means of struggle against the material practices of contemporary capitalism. To this end, I shall indicate how overdetermination in conceptualization provides the opportunity to break down identity-thinking and how articulation can translate the material elements of contemporary capitalism into fresh moments of a counter-hegemonic discourse. (shrink)

This book interprets Max Stirner's The Ego and Its Own as a critique of modernity and traces the basic elements of his dialectical egoism through the writings of Benjamin Tucker, James L. Walker, and Dora Marsden. Stirner's concept of 'ownness' is the basis of his critique of the dispossession and homogenization of individuals in modernity and is an important contribution to the research literature on libertarianism, dialectics, and post-modernism.

This article offers a critical theoretical exploration of the transformation of academic life that is currently taking place under the sign of ‘neoliberalization’. The main aim is to differentiate appropriation from exploitation as strategies of surplus labour dispossession, to identify the growth of appropriative techniques in academic life, and to situate the proliferation of such techniques in the broader transformations of global political economy. Alloyed with poststructuralist social theory, the historical materialist thrust of the article demonstrates how, in the technologically (...) articulate ‘social factory’ of advanced capitalism, the spatial operations of these techniques of dispossession have a particularly ‘aesthetic’ character that is immanent to their appropriative operation, and which renders their workings both more discreet and effective. The article aims: (1) to problematize the neoliberal concepts of efficiency, transparency, and autonomy, in terms of practical outcomes; (2) to stimulate reflexive consideration of the ‘positioning’ of academics themselves in the reproduction of these techniques; and (3) to ask how these techniques might generate new ‘historical subjects’ of struggle and organization in academic life. (shrink)

Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Abstractabstract:Though the prospect seems a million miles away, interest in the end of capitalism has been as longstanding as it is utopian, but do we really understand what we mean when we speak of the end of capitalism? Maybe we have things the wrong way round, and in our understandable preoccupation with the future we fail to appreciate how prospective ends often lie in the past. While the expression might refer to practices, experiences, and real social relations, capitalism is a (...) conceptualization and as such is a synthetic product of the understanding. Between abstraction and the concrete, could the end of capitalism lurk somewhere in this activity? Might it be something we can experience but never know? Is our expectation of paradigmatic transformation counterproductive? Is there a role for utopias and utopianism in this, and if so what might that be? (shrink)

ABSTRACTThis article attempts a properly critical and political analysis of the “police power” immanent to the form and logic of academic rankings, and which is reproduced in the extant academic literature generated around them. In contrast to the democratising claims made of rankings, this police power short-circuits the moment of democratic politics and establishes the basis for the oligarchic power of the State and its status quo. Central in this founding political moment is the notion of the Arkhè, a necessarily (...) asymmetric “distribution of the sensible” that establishes the basis of the political order, in this case an oligarchic political order. Drawing on Foucault and Rancière, the article argues for a necessary “dissensus” with both the ranking practice and its attendant academic literature, as the first step towards a politics of ranking that is properly critical, and therefore genuinely political. (shrink)

So much of what we experience in neoliberal capitalism resembles the operation of the camp. How then can we understand the camp as a political technology of labour control recurrent in historical capitalism, and why would we want to? Driven by the perennial imperatives to govern and to accumulate, the camp as a modulation of social control allows us to explore the role of ‘meta-disciplinary’ technique in the ‘real subsumption of labour’. The aims here are to question the sanguine expectations (...) of a liberal pastorate that is inextricable from the needs of capital; to articulate the ‘techniques of domination’ experienced in the idiom of neoliberal capitalism; and to find inspiration for corresponding counter-conducts and ‘techniques of the self’. This article offers a kind of historical archaeology of ‘meta-disciplinary’ technique by resuscitating Solzhenitsyn’s The Gulag Archipelago, a surprisingly rich source of insight into the operations of the camp modulation and the counter-conducts it engenders. The analysis to follow works in the space between Marxian and Foucauldian political thought opened up by the new materialisms, and draws upon the recent works of Lordon, Lazzarato, Negri, inter alia, that are currently enriching critical theory. (shrink)

Now over a decade since the publication of John Michael’s Anxious Intellects (2000), many rhetoric scholars are no less anxious about the relevance of scholarship to public affairs. Recent exchanges concerning rhetorical criticism, public intellectualism, and academic engagement continue to provide evidence of a prominent felt need to prove public relevance, explain away the lack of readily apparent public engagement, or adopt a more activist posture. That academic work should have political consequences is broadly assumed within a dominant strain (...) of rhetorical scholarship owing to what is doubtless an incontrovertible feature of reality—words have political consequences. From this fact, many rhetoric scholars .. (shrink)

Science (episteme) -- Division of the sciences according to aims and objects -- Demonstration (apodeixis) -- The axioms of the sciences -- Being or substance (ousia) -- Being before aristotle -- Being in the categories -- The science of being: first philosophy -- Being in metaphysics zeta -- Nature (physis) -- Principles of change -- The four causes or explanations (aitiai) -- Defense of teleology -- Soul (psyche) -- Soul as substance, form and actuality -- What the student of soul (...) investigates -- Perception -- Thought -- Success (eudaimonia) -- The practical science of ethics -- The chief and final good for human beings -- Virtues of character -- Virtues of intellect. (shrink)

Written as companion texts, the Bendō 弁道 and the Benmei 弁名 present Ogyū Sorai’s most mature and comprehensive expression of his philosophical thought. Sorai modestly spoke of the texts in a letter to a student, Uno Shirō 宇野士朗, calling them “my humble achievements”. In another letter to a student, Yamagata Shūnan 山県周南, Sorai related that after a prolonged bout with ill-health, he feared passing like the morning dew. Therefore, he took up his writing brush and completed the two works. Sorai (...) added that while more than a millennium had passed since Confucius’ death, the Way had only been clarified in recent times. Yet rather than boast of this, Sorai suggested that his hand in the process had been by heaven’s decree. With the two works, he added that even if he passed away soon, his life would not have been wasted. (shrink)

This paper explores Ogyū Sorai’s 荻生徂徠 thinking on the most sensational and controversial incident of eighteenth-century Japan, and perhaps the most well-known in all Japanese history, the forty-seven rōnin incident of 1701–1703. Viewed in relation to his lifework, Sorai’s views on the incident are significant insofar as they reveal the extent to which his philosophical thinking was occasionally shaped decisively by neither ancient Chinese nor later Confucian texts, Neo- or otherwise, but instead by formative life-experiences he had as a youth (...) living in exile. No doubt, Confucian and Neo-Confucian notions, which Sorai knew in-depth, helped him filter, epistemologically, events, issues, and most importantly what he understood to be righteous and just behaviour in a polity. Yet ironically enough, Sorai’s thinking on the rōnin incident shows that however philosophically erudite, cosmopolitan, and urbane he was as an intellectual, his appraisals of things sometimes harked back to rural experiences he had early on with some of the most primitive and foundational expressions of human agency, civilization, and socio-political ethics in early-eighteenth century Japan. In the process, Sorai’s essay reveals, through its later resonance with some Meiji thought, how his views on those same primitive expressions remained relevant even in modern contexts. (shrink)

This study examines Itō Jinsai’s 伊藤仁斎 (1627–1705) criticisms of the Great Learning (C: Daxue 大學 J: Daigaku). Three primary sources are considered: Jinsai’s Shigi sakumon 私擬策問 (Personal Essays, 1668); the Daigaku teihon 大學定本 (The Definitive Text of the Great Learning, manuscript 1685); and his essay, “Daigaku wa Kōshi no isho ni arazaru no ben” 大學非孔氏之遺書辨 (The Great Learning is not a Writing Confucius Transmitted, 1705), appended to his Gomō jigi 語孟字義. The study suggests that Jinsai’s critical inclinations grew from his (...) acceptance of Zhu Xi’s views about the value of doubt for progress in learning. The study also suggests that Jinsai’s thinking on the Great Learning had political implications derived in many respects from Jinsai’s overall approach to philosophizing via analysis of words and their meanings. (shrink)

This book constructs a new scientific explanation of the causes of war. The author describes systematically those factors common to wars between equal states to see if there is a pattern that suggests why war occurs and delineates the typical path by which relatively equal states have become embroiled in wars with one another in the modern global system. The book differs from others in that it employs the large number of empirical findings generated in the past twenty-five years to (...) solve the puzzle of war and peace. (shrink)

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections (...) in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ The Ethics Of George Eliot's Works 3 John Crombie Brown W. Blackwood, 1880 Literary Criticism; European; English, Irish, Scottish, Welsh; Literary Criticism / European / English, Irish, Scottish, Welsh; Literary Criticism / Women Authors. (shrink)

This chapter argues that scientific and philosophical progress in our understanding of the living world requires that we abandon a metaphysics of things in favour of one centred on processes. We identify three main empirical motivations for adopting a process ontology in biology: metabolic turnover, life cycles, and ecological interdependence. We show how taking a processual stance in the philosophy of biology enables us to ground existing critiques of essentialism, reductionism, and mechanicism, all of which have traditionally been associated with (...) substance ontology. We illustrate the consequences of embracing an ontology of processes in biology by considering some of its implications for physiology, genetics, evolution, and medicine. And we attempt to locate the subsequent chapters of the book in relation to the position we defend. (shrink)

This is a translation of the chapter on perception by Kumarilabhatta's magnum opus, the Slokavarttika , which is one of the central texts of the Hindu response to the criticism of the logical-epistemological school of Buddhist thought. It is crucial for understanding the debates between Hindus and Buddhists about metaphysical, epistemological and linguistic questions during the classical period. In an extensive commentary, the author explains the course of the argument from verse to verse and alludes to other theories of classical (...) Indian philosophy and numerous other technical matters. Notes to the translation and commentary go further into the historical and philosophical background of Kumarila's ideas. The book provides an introduction to the history and the development of Indian epistemology, a synopsis of Kumarila's work and an analysis of its argument. It is a valuable contribution to the field of Indian philosophical studies. (shrink)

Education, Religion and Society celebrates the career of Professor John Hull of the University of Birmingham, UK, the internationally renowned religious educationist who has also achieved worldwide fame for his brilliant writings on his experience, mid-career, of total blindness. In his outstanding career he has been a leading figure in the transformation of religious education in English and Welsh state schools from Christian instruction to multi-faith religious education and was the co-founder of the International Seminar on Religious Education (...) and values. John Hull has also made major contributions to the theology of disability and the theological critique of the "money culture." This volume brings together leading international scholars to honour John Hull's contribution, with a focus on furthering scholarship in the areas where he has been active as a thinker. The book offers a critical appreciation of his contribution to religious education and practical theology, and goes on to explore the continuing debate about the role of religious education in promoting international understanding, intercultural education and human rights education. A possible basis for integrating Islamic education into Western education is suggested and the contribution of the philosophy of religion to pluralistic religious education is outlined. The contributors also deal with issues relating to indoctrination, racism and relationship in Christian religious aspects, and examines aspects of the the theology of social exclusion and disability. (shrink)

As genomic science has evolved, so have policy and practice debates about how to describe and evaluate the ways in which genomic information is treated for individuals, institutions, and society. The term genetic exceptionalism, describing the concept that genetic information is special or unique, and specifically different from other kinds of medical information, has been utilized widely, but often counterproductively in these debates. We offer genomic contextualism as a new term to frame the characteristics of genomic science in the debates. (...) Using stasis theory to draw out the important connection between definitional issues and resulting policies, we argue that the framework of genomic contextualism is better suited to evaluating genomics and its policy-relevant features to arrive at more productive discussion and resolve policy debates. (shrink)

[Edited from Conclusion section:] We have looked at various challenging issues to do with getting connectionism to cope with high-level cognitive activities such a reasoning and natural language understanding. The issues are to do with various facets of generalization that are not commonly noted. We have been concerned in particular with the special forms these issues take in the arena of propositional attitude processing. The main problems we have looked at are: (1) The need to construct explicit representations of generalizations, (...) not just generalize correctly to individual cases; (2) The need to be able to match two or more complex short-term information structures, to enable rapid generalization from recent examples rather than from long-term memories; (3) The need to represent and reason with anomalous combinations of concepts; (4) The need to perform embedded reasoning. This presents special problems for systems using non-concatenative representations (as in mainstream connectionist approaches). We also touched on vague quantification in attitude report complements. Neither this topic nor that of analogies between short-term structures (point 2) has been adequately addressed in the symbolic framework, let alone in connectionism. -/- The opportunities and problems covered are put forward as things worth being optimistic about or pessimistic about, respectively. They are not put forward as decisive arguments for or against connectionism. The hope is that this chapter contributes to a greater understanding of the connectionist/symbolist gap by presenting some unusual issues and by throwing new light on some well known ones. (shrink)

This book offers geographical perspectives on the condition of the United States at the outset of the twenty-first century. It compares the American ideals of liberty, equality, individual opportunity, and social improvement with the contemporary condition of the regions, states and localities - the ideal American space with its reality as a place. It uses the public standard provided by the official ideology of the United States to see how well things are really going. The authors consider the contrast between (...) ideal and reality at local, state, and national levels in education, health, and welfare, in community, race, gender, and class relations, in economic and industrial development, and in the use and exploitation of America's landscape. Each chapter addresses the issues through evidence of long-term and recent trends, and grounds its arguments in information. American Space/American Place provides a series of compelling insights into the current condition of American society, its natural environment, and its place within the world. (shrink)

Broad in scope and edited by two massive names in geography, this is a critical exploration of how the field has emerged and fared over the course of its modern institutionalization.

This is a translation of the chapter on perception of Kumarilabhatta's magnum opus, the Slokavarttika, one of the central texts of the Hindu response to the criticism of the logical-epistemological school of Buddhist thought. In an extensive commentary, the author explains the course of the argument from verse to verse and alludes to other theories of classical Indian philosophy and other technical matters. Notes to the translation and commentary go further into the historical and philosophical background of Kumarila's ideas. The (...) book provides an introduction to the history and the development of Indian epistemology, a synopsis of Kumarila's work and an analysis of its argument. (shrink)

Schumaker (philosophy, science and technology department, Rensselaer Polytechnic Institute) examines how the terms of posture encompass all the major disciplines and investigates a variety of philosophical topics: abstract thought, ...

"The book provides an excellent historical summary of the debates over continental drift theory in this century." —Contemporary Sociology "This is a useful discussion of the way that science works. The book will be of value to philosophers of science... " —Choice "... will find an important place in university and department libraries, and will interest afficionados of the factual and intellectual history of the earth sciences." —Terra Nova "... an excellent core analysis... " —The Times Higher Education Supplement "... (...) an ambitious and important contribution to the new sociology of science." —American Journal of Sociology "... Stewart's book is a noble effort, an interesting and readable discussion, and another higher notch on the scoreboard of critical scholarship that deserves wide examination and close attention." —Geophysics This fascinating book describes the rise and fall and rebirth of continental drift theory in this century. It uses the recent revolution in geoscientinsts' beliefs about the earth to examine questions such as, How does scientific knowledge develop and change? The book also explores how well different perspectives help us to understand revolutionary change in science. (shrink)

Word Order Universals is a detailed account of word order universals and their role in theories of historical change. The starting point is the Greenberg data set, which is comprised of a sample of 142 languages for certain limited co-occurrences of basic word orders, and a 30-language sample for more detailed information. In the Language Index, the 142 have been expanded to some 350 languages. Using the original Greenberg samples and the Expanded Sample, an alternative set of descriptive word order (...) statements is provided. Comprised of eight chapters, this book begins with an introduction to the theory of word order universals, encompassing topics such as word order variation across languages and theories of universal grammar. The reader is then introduced to the work of Joseph Greenberg and Theo Vennemann on word order universals; implicational universals in Greenberg's data and the Expanded Sample; and the predictions made by implicational and distributional universals for word order change. Reformulated universals for historical reconstruction are also discussed, along with some laws of reconstruction derived from synchronic universals. The final chapter is devoted to the Expanded Sample, with particular reference to its quantities as well as its typological and genetic classification. This monograph will be a useful resource for specialists in grammar and linguistics. (shrink)

Paraphrase is ubiquitous in philosophy, especially in discussions about ontological commitment. But should it be? Paraphrases are seldom accompanied by evidence that would convince, say, a linguist that the paraphrase and the paraphrased sentence have the same meaning. Indeed, from the perspective of linguistics, many paraphrases would seem to be nothing but bad jokes. For this reason, many philosophers have become deeply suspicious about paraphrase. I ague in this paper that this worry is misguided--that successful paraphrases do not need to (...) preserve semantic content, and that the way that paraphrase has been used in Quinean meta-ontology, and philosophical inquiry more generally, corresponds, at least roughly, to the way it should be used. (shrink)

The scarcity of vital organs has prompted several calls to either modify the dead donor rule or interpret it more broadly. Given its symbolic importance, however, the rule should be changed only cautiously.

The scarcity of vital organs has prompted several calls to either modify the dead donor rule or interpret it more broadly. Given its symbolic importance, however, the rule should be changed only cautiously.

This volume is a state-of-the-art review of the evidence and theory supporting the existence and significance of automatic processes in our daily lives, with chapters by the leading researchers in this field today.

This article examines the role of emotion experience in both rational action and self-knowledge. A key distinction is made between emotion experiences of which we are unaware, and those of which we are aware. The former motivate action and color our view of the world, but they do not do so in a rational way, and their nonreflective nature obscures self-understanding. The article provides arguments and evidence to support the view that emotion experiences contribute to rational action only if one (...) is appropriately aware of them (because only then does one have the capacity to inhibit one's emotional reactions). Furthermore, it is argued that awareness of emotion increases self-knowledge because it is a source of information about our biases. (shrink)

There is a puzzle about the use of paraphrase in philosophy, presented most famously in Alston's [1958] ‘Ontological Commitments’, but found throughout the literature. The puzzle arises from the fact that a symmetry required for a paraphrase to be successful seems to necessitate a symmetry sufficient for a paraphrase to fail, since any two expressions that stand in the means the same as relation must also stand in the has the same commitments as relation. I show that, while this problem (...) does undermine some conceptions of paraphrase, on a proper understanding of paraphrase the puzzle gets no purchase. Since paraphrase is an important component of Quinean approaches to meta-ontology, this paper constitutes a partial defence of Quinean meta-ontology. Since paraphrase is an important component of traditional methods of philosophical inquiry, this paper constitutes a partial defence of traditional modes of philosophizing as well. (shrink)

"The world's leading expert on the unconscious mind reveals the hidden mental processes that secretly govern every aspect of our behavior. For more than three decades, Dr. John Bargh has been conducting revolutionary research into the unconscious mind--not Freud's dark, malevolent unconscious but the new unconscious, a helpful and powerful part of the mind that we can access and understand through experimental science. Now Dr. Bargh presents an engaging and enlightening tour of the influential psychological forces that are at (...) work as we go about our daily lives--checking a dating app, holding a cup of hot coffee, or getting a flu shot. Dr. Bargh takes you into his labs at New York University and Yale where his ingenious experiments have shown how the unconscious guides our actions, goals and motivations in areas like race relations, parenting, business, consumer behavior, and addiction. He reveals the pervasive influence of the unconscious mind on who we choose to date or vote for, what we buy, where we live, how we perform on tests and in job interviews, and much more. Before You Know It is full of surprising and entertaining revelations as well as tricks to help you remember to-do items, shop smarter, and sleep better. Before You Know It will profoundly change the way you understand yourself by introducing you to a fascinating world only recently discovered, the world that exists below the surface of your awareness and yet is the key to unlocking new ways of thinking, feeling and behaving."--Jacket. (shrink)